Functional DNA Nanotechnology
Figure 1. DNA “codes” for nanomaterial morphology.
Figure 2. Stimuli-responsive assembly of different nanomaterials
Figure 3. DNA-mediated synthesis of bimetallic nanoparticles

We are interested in discovering “genetic codes” for nanomaterial shapes and surface properties (i.e., morphologies), as well as precise spatial and dynamic control over nanomaterials assembly.

In the process, we strive to understand the roles of functional DNA (i.e., DNAymes and aptamers) in controlling the synthesis and assembly of many different nanomaterials including gold nanoparticles, quantum dots, carbon nanotubes and nanodots, lanthanide-doped upconversion nanoparticles, and supermagnatic iron oxide nanoparticles.

We believe that nanomaterial genetic coding may be developed into a universal, programmable method for determining nanomaterial morphology. With this tool, we are developing highly sensitive and selective sensors, imaging agents, and theranostic agents aimed at detection and treatment of toxic chemicals and diseases such as cancers.

For a general overview of this area, please see the following review articles:
Acc. Chem. Res. (2007), Acc. Chem. Res. (2014), J. Mater. Chem., and Curr. Opin. Chem. Biol.

(Click Title to View the Presentation)