The Lu group's interests lie at the interface between chemistry and biology. We are developing innovative chemical approaches to provide deeper insight into biological structures and functions. We are also taking advantage of recently developed biological tools to advance many areas in chemistry, such as inorganic chemistry, chemical biology, analytial chemistry, and materials chemistry. We strive to make significant contributions in three principal areas of research:

  1. Biosynthetic Inorganic Chemistry
  2. Synthesis and study of structural and functional mimics of metalloenzymes and their applications as biocatalysts in renewable energy generation and small-molecule activation and transformation.

  3. Metallo-DNAzymes
  4. In vitro selection of catalytic DNA molecules and development of highly sensitive and selective sensors and imaging agents for metal ions and small-molecule targets with applications in environmental monitoring, food safety, and medical imaging and diagnostics.

  5. Functional DNA Nanotechnology:
  6. Using DNA for encoded synthesis and directed assembly of nanomaterials and their applications as theranostic agents for early detection and treatment of toxic chemicals and diseases such as cancers.

On May 14, seven recently graduated PhDs from the Lu group
attended the 2016 Commencement.

Recent News
2016 06 21 | Now We "NO" | A recent publication by Shiliang Tian and others has been featured in a Nature Chemistry editorial on elucidating the mechanism for reversible NO binding to T1 copper centers in proteins such including azurin.
2016 04 05 | Fellowship Awarded to Recent Lu Lab Graduate | Congratulations to recently-graduated lab member Ambika Bhagi-Damodaran for being awarded the Faculty for the Future Fellowship from the Schlumberger Foundation for the 2016-2017 academic year.
2015 12 02 | Chemists Acheive Wider-Than-Ever Redox Range | Work by Parisa Hosseinzadeh and others in the Lu group has been highlighted by C&EN and given a commentary by PNAS for the successful engineering of the entire physiological redox range into a single protein scaffold, azurin.
2015 11 24 | Having Biomarkers at the Fingertips | A recent publication by JingJing Zhang, et al, has been highlighted in Angewandte Chemie for their work to expand the utility of the common glucose meter.